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E2600Mo

Mouse Transcription Factor 7, TCF7 ELISA Kit

Bioassay Technology Laboratory

DESCRIPTION

Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. Represses expression of the T-cell receptor gamma gene in alpha-beta T-cell lineages (PubMed: 17218525). Inhibits the developmental program of IL17A effector gamma-delta T-cell subsets via regulating the transcription of T-cell lineage effector proteins (PubMed: 23562159, PubMed: 30413363). Required for the development of natural killer receptor-positive lymphoid tissue inducer T-cells (PubMed: 23562159). TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1 (By similarity). May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes.

DETAILS

  • GeneID: 21414
  • Species: Mouse
  • Storage: 2-8ºC
  • MASS(Da): 45,465
  • Synonyms: T-cell factor 1;T-cell-specific transcription factor 1;TCF 7;TCF-1;TCF7;TCF-7;Transcription factor 7
  • Assay Time: 1h 30m
  • Assay Type: Sandwich
  • Gene Names: TCF7
  • Reactivity: Mouse
  • Sample Type: Serum, plasma, cell culture supernates
  • Sensitivity: 0.021ng/ml
  • Target Protein: TCF7
  • Detection Range: 0.05-20ng/ml
  • Full Product Name: Transcription Factor 7
  • Standard Solution: 24ng/ml
  • UniProt Accession: Q00417