Recombinant Murine IL-10

DESCRIPTION

IL-10 is an immunosuppressive cytokine produced by a variety of mammalian cell types including macrophages, monocytes, T cells, B cells and keratinocytes. IL-10 inhibits the expression of proinflammatory cytokines such as IL-1 and TNF-alpha. Like IL-4, IL-10 enhances humoral immune responses and attenuates cell-mediated immune reactions. Human IL-10 is active on murine cells, but murine IL-10 is inactive on human cells. Recombinant Murine IL-10 is an 18.7 kDa protein of 161 amino acid residues.

DETAILS

Gene Id: 16153
Uniprot: P18893
Activity: PeproTech's Murine IL-10 is fully biologically active as measured by the dose-dependent co-stimulation (with IL-4) of the proliferation of murine MC/9 cells. The ED50 was found to be ≤ 2 ng/ml, corresponding to a specific activity of ≥ 5 x 10^5 units/mg.
Category: RUO Cytokines
Subcategory: Growth Factors & Cytokines
Research Areas: AIDS/HIV, Cancer, Immune System, Inflammation, Neurobiology, Stem Cells and Differentiation, Allergy, Transplantation, COVID-19
Alternative Names: B-TCGF, CSIF, TGIF
Species of Origin: Murine
Expression System Source: E.coli