mouse monoclonal IgG1; IP3KA Antibody (F-3) is an IgG1 κ mouse monoclonal IP3KA antibody (also designated IP3KA antibody) that detects the IP3KA protein of mouse, rat and human origin by WB, IP, IF and ELISA. IP3KA Antibody (F-3) is available as both the non-conjugated anti-IP3KA antibody form, as well as multiple conjugated forms of anti-IP3KA antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) regulates the level of calcium within the cell by releasing calcium from intracellular stores (1-3). Ins(1,4,5)P3 is phosphorylated by inositol 1,4,5-trisphosphate 3-kinase (IP3K) to form inositol 1,3,4,5-tetrakisphosphate (Ins(1,4,5)P4), which is is thought to regulate the influx of calcium across the plasma membrane (2,3). IP3K exists as three isoforms, IP3KA, B, and C (3,4). IP3KA, the most highly characterized isoform, is expressed in rat brain and testis (3-5). IP3KB is expressed in various rat tissues such as lung, thymus, testis, brain, and heart (3,4). IP3K activity is stimulated in the presence of calmodulin via phosphorylation by cAMP-dependent protein kinase, protein kinase C, or calcium/calmodulin dependent protein kinase II and, subsequently, mediates the inositol phosphate signaling pathways (3,5-7).

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.