RP01698
Recombinant Human TNFRSF9/4-1BB/CD137 Protein
ABclonal
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DESCRIPTION
CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necrosis factor (TNF) receptor superfamily. It is expressed mainly on activated CD4+ and CD8+ T cells, and binds to a high-affinity ligand (4-1BBL) expressed on several antigen-presenting cells such as macrophages and activated B cells. Upon ligand binding, 4-1BB is associated with the tumor necrosis factor receptor–associated factors (TRAFs), the adaptor protein which mediates downstream signaling events including the activation of NF-kappaB and cytokine production. 4-1BB signaling either by binding to 4-1BBL or by antibody ligation delivers signals for T-cell activation and growth, as well as monocyte proliferation and B-cell survival, and plays an important role in the amplification of T cell-mediated immune responses.
DETAILS
- Tag: C-6His
- Source: HEK293 cells
- Gene Id: 3604
- Species: Human
- Lead Time: 3-5 weekdays
- Swiss Prot: Q07011
- Research Areas: Immune Checkpoint
- Alternative Names: ILA; 4-1BB; CD137; CDw137;TNFRSF9
Equivalent Items
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