Anti-Ksp-Cadherin (Kidney-Specific Cadherin) / CDH16 Recombinant Mouse Monoclonal Antibody (Clone:rCDH16/1071)

DESCRIPTION

This MAb recognizes a protein of 130kDa, identified as Ksp-cadherin. Cadherins form a superfamily of related glycoproteins that mediate calcium-dependent cell adhesion and transmit signals from the extracellular matrix to the cytoplasm. Cadherins have been implicated in embryogenesis, tissue morphogenesis, tissue structure maintenance, cell polarization, neoplastic invasiveness and metastasis, and membrane transport. It is sµggested that Ksp-cadherin is a marker for terminal differentiation of the basolateral membranes of renal tubular epithelial cells. Within the kidney, Ksp-Cadherin is found exclusively in the basolateral membrane of renal tubular epithelial cells and collecting duct cells, and not in glomeruli, renal interstitial cells, or blood vessels. Ksp-Cadherin has been sµggested to distinguish Chromophobe Renal-Cell Carcinoma from Oncocytoma.

DETAILS

Gene: CDH16
App Id: FACS,WB,IHC
Gene Id: 1014
Isotype: Mouse IgG1, kappa
Format Id: Purified
Clone Name: rCDH16/1071
Uniprot Id: O75309
Host Animal: Mouse
Clonality Id: Monoclonal
Purification: Protein A/G
Reactivity Id: Human, Mouse, Rat
Product Content: 200µg/ml of recombinant MAb purified by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Alternative Name: Cadherin-16 (CDH16); Kidney-specific cadherin; Ksp-cadherin antibody
Application Note: Flow Cytometry (1-2µg/million cells); Western Blot (1-2µg/ml); Immunohistochemistry (Formalin-fixed) (1-2µg/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95&degC followed by cooling at RT for 20 minutes);
Storage Condition: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.
Immunogen Information: Recombinant full-length human CDH16 protein