RP01522
Recombinant Human CD8a Protein
ABclonal
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DESCRIPTION
T-cell surface glycoprotein CD8 alpha chain, also known as CD8a, is a single-pass type I membrane protein. The CD8 glycoprotein is expressed by thymocytes, mature T cells and natural killer (NK) cells and has been implicated in the recognition of monomorphic determinants on major histocompatibility complex (MHC) Class I antigens, and in signal transduction during the course of T-cell activation. Both human and rodent CD8 antigens are comprised of two distinct polypeptide chains, alpha and beta. The Ig domains of CD8 alpha are involved in controlling the ability of CD8 to be expressed. Mutation of B- and F-strand cysteine residues in CD8 alpha reduced the ability of the protein to fold properly and, therefore, to be expressed. Defects in CD8A are a cause of familial CD8 deficiency. Familial CD8 deficiency is a novel autosomal recessive immunologic defect characterized by absence of CD8+ cells, leading to recurrent bacterial infections.
DETAILS
- Tag: C-raFc
- Source: HEK293 cells
- Gene Id: 925
- Species: Human
- Lead Time: 3-5 weekdays
- Swiss Prot: P01732
- Research Areas: Other Recombinant Protein
- Alternative Names: CD8, Leu2, MAL, p32,CD8A,Leu2,MAL,p32
Equivalent Items
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