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2935595-50mg 2935595-10mg

T 0901317

Biogems

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DESCRIPTION

T 0901317 is a potent agonist for the high affinity liver X receptor, which up-regulates ABC1 gene expression. It is reported that it can be used to lower cholesterol levels in serum and liver, to suppress the proliferation of breast and prostate cancer cells, and to decrease amyloid beta production.

DETAILS

  • Purity: ≥98%
  • Synonyms: T-0901317, T0901317
  • Cas Number: 293754-55-9
  • References: Koldamova, R. P., Lefterov, I. M., Staufenbiel, M., Wolfe, D., Huang, S., Glorioso, J. C., ... & Lazo, J. S. (2005). The liver X receptor ligand T0901317 decreases amyloid β production in vitro and in a mouse model of Alzheimer's disease. Journal of Biological Chemistry, 280(6), 4079-4088. Mitro, N., Vargas, L., Romeo, R., Koder, A., & Saez, E. (2007). T0901317 is a potent PXR ligand: implications for the biology ascribed to LXR. FEBS letters,581(9), 1721-1726. Chisholm, J. W., Hong, J., Mills, S. A., & Lawn, R. M. (2003). The LXR ligand T0901317 induces severe lipogenesis in the db/db diabetic mouse. Journal of lipid research, 44(11), 2039-2048.
  • Application: FA
  • Formulation: Crystalline solid
  • Chemical Name: N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamide
  • Molecular Weight: 481.3
  • Molecular Formula: C17H12F9NO3S
  • Storage Conditions: Product should be kept at -20°C.
  • Pubchem Openeye Can Smiles: C1=CC=C(C=C1)S(=O)(=O)N(CC(F)(F)F)C2=CC=C(C=C2)C(C(F)(F)F)(C(F)(F)F)O