CT4-R52H4-100ug CT4-R52H4-1mg
Rabbit CTLA-4 / CD152 Protein, His Tag
ACROBiosystems
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DESCRIPTION
CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is also known as CD152 (Cluster of differentiation 152), is a protein receptor that downregulates the immune system. CTLA4 is a member of the immunoglobulin superfamily, which is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. The protein contains an extracellular V domain, a transmembrane domain, and a cytoplasmic tail. Alternate splice variants, encoding different isoforms. CTLA4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function. Fusion proteins of CTLA4 and antibodies (CTLA4-Ig) have been used in clinical trials for rheumatoid arthritis.
DETAILS
- Tag: C-10×His
- Host: HEK293
- Size: 100ug
- Buffer: PBS, pH7.4
- Format: Powder
- Source: Rabbit CTLA-4, His Tag (CT4-R52H4) is expressed from human 293 cells (HEK293). It contains AA Lys 36 - Asp 161 (Accession # P42072-1).
- Storage: -20℃
- Category: Immune Checkpoint Proteins
- Molecule: CTLA-4
- Accession: NP_001076154.1
- Conjugate: Unconjugated
- Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
- Exp Region: Lys 36 - Asp 161
- Swiss-prot: P42072-1
- Package Size: 100ug*1
- Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 15.5 kDa.
- Endotoxin Level: 1.0 EU per μg
- Molecular Weight: 15.5 kDa
- Shipping Condition: RT
- Species Reactivity: Rabbit
- Extra Shippinghandling Fee: Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/A48-Shipping-and-Payments.html