Phospho-TOPBP1(S1138) Blocking Peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 11073
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: TOPBP1
Other Names: DNA topoisomerase 2-binding protein 1, DNA topoisomerase II-beta-binding protein 1, TopBP1, DNA topoisomerase II-binding protein 1, TOPBP1, KIAA0259
Availability: 2 weeks
Bio Background: This gene encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of topoisomerase II beta through transient breakages of DNA strands.
Bio References: Huo, Y.G., et al. Biochem. Biophys. Res. Commun. 401(3):401-405(2010) Blackford, A.N., et al. Proc. Natl. Acad. Sci. U.S.A. 107(27):12251-12256(2010) Takeishi, Y., et al. Genes Cells 15(7):761-771(2010) Gong, Z., et al. Mol. Cell 37(3):438-446(2010) Couch, F.J., et al. Cancer Epidemiol. Biomarkers Prev. 19(1):251-257(2010)
Other Accession: Q6ZQF0; NP_008958.2
Primary Accession: Q92547
Targetspecificity: The synthetic peptide sequence is selected from aa 1130-1142 of HUMAN TOPBP1