sc-293184 SAMPLE sc-293184
Promo Available
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p35 (4G11)
Santa Cruz Biotechnology
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DESCRIPTION
mouse monoclonal IgG2a; p35 Antibody (4G11) is an IgG2a κ mouse monoclonal p35 antibody (also designated CDK5R1 antibody or CDK5 activator 1 antibody) that detects the p35 protein of mouse, rat and human origin by WB, IP, IF and ELISA. p35 Antibody (4G11) is available as the non-conjugated anti-p35 antibody. Cyclin dependent kinase-5 (Cdk5), a key regulator of cell cycle progression, was originally isolated on the basis of its structural homology to Cdc2, a well-characterized regulator of cell cycle progression. Although Cdk5 is expressed at the highest level in the brain of adult mice, intermediate levels in testis and low or undetectable levels in all other tissues, brain is the only tissue from which Cdk5 can be isolated as an active kinase. These findings may be explained by the cloning and characterization of a Cdk5 regulatory subunit, designated p35. p35 displays a neuronal cell-specific pattern of expression, physically associates with Cdk5 and activates Cdk5 enzymatic activity. p35 is also expressed in many tissues in a truncated form, designated p25.
DETAILS
- Host: mouse
- Type: Primary
- Uniprot: Q15078
- Clonality: Monoclonal
- Conjugate: unconjugated
- Applications: WB, IP, IF, ELISA
- Human Gene Id: 8851
- Mouse Gene Id: 12569
- Protein Target: p35
- Human Gene Name: CDK5R1
- Mouse Gene Name: Cdk5r1
- Species Reactivity: mouse, rat, human
PROMOTION TERMS
Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.
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