Anti-CD117 / c-Kit (Marker for Gastrointestinal Stromal Tumors) Monoclonal Antibody(Clone: KIT/2673)

DESCRIPTION

This MAb recognizes a protein of 145kDa, identified as CD117/p145kit. It is found on a wide variety of tumor cells including follicular and papillary carcinoma of thyroid, adenocarcinomas from endometrium, lung, ovary, pancreas, and breast as well as malignant melanoma, endodermal sinus tumor, and small cell carcinoma. However, anti-CD117 has been particularly useful in differentiating gastrointestinal stromal tumors from Kaposi's sarcoma, tumors of smooth muscle origin, fibromatosis, and neural tumors of the GI tract. Anti-CD117 is also useful in recognizing myeloblasts in bone marrow biopsy and clot section.

DETAILS

Gene: KIT
App Id: ELISA,FACS,WB
Gene Id: 3815
Isotype: Mouse IgG1, kappa
Clone Name: KIT/2673
Uniprot Id: P10721
Host Animal: Mouse
Clonality Id: Monoclonal
Reactivity Id: Human
Product Content: 200 µg/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Alternative Name: p145; Steel Factor Receptor; Stem Cell Factor Receptor (SCF-Receptor); Mast Cell Growth Factor Receptor
Application Note: ELISA (For coating, order antibody without BSA); Flow Cytometry (1-2ug/million cells); Western Blot (1-2ug/ml);
Storage Condition: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.
Immunogen Information: Recombinant full-length human KIT protein