mouse monoclonal IgG1; PARD6A Antibody (C-3) is an IgG1 κ mouse monoclonal PARD6A antibody (also designated PAR6 antibody or PAR6A antibody) that detects the PARD6A protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. PARD6A Antibody (C-3) is available as both the non-conjugated anti-PARD6A antibody form, as well as multiple conjugated forms of anti-PARD6A antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Cellular asymmetry is critical for the development of multicellular organisms. PARD (partitioning-defective) proteins play important roles in asymmetric cell division and polarized growth, whereas Cdc42 and Rac mediate establishment of cell growth and polarity and contribute to oncogenic transformation by Ras. The human PARD6, a 345 amino acid polypeptide, has a PDZ domain and a CRIB-like (Cdc42/Rac interactive binding) motif. PARD6 interacts with GTP-bound Rac and Cdc42 via this motif and with the atypical PKC isoforms PKCι/λ and PKCΩ via N-terminal head to head association. These interactions allow formation of a ternary complex in vitro and in vivo, which is implicated in the formation of normal tight junctions at epithelial cell-cell contacts and is also involved in the polarization of mother cells before asymmetric cell division in C. elegans. PARD6 acts through PARD3 by localizing or maintaining the PARD3 protein at the cell periphery. PARD6A, also designated PAR-6α, PAR6C, TAX40 and TIP-40, is expressed in pancreas, skeletal muscle, brain and heart, and is weakly expressed in kidney and placenta. PAR6B is expressed in pancreas and in both adult and fetal kidney, and is weakly expressed in placenta and lung.

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.