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37433

DTHIB

Cayman Chemical

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DETAILS

  • Inchi: InChI=1S/C13H9ClFN3O3/c14-11-6-5-10(7-12(11)18(20)21)17-13(19)16-9-3-1-8(15)2-4-9/h1-7H,(H2,16,17,19)
  • Purity: ≥98%
  • Raptas: Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer|Cell Cycle|G1||Research Area|Cancer|Cell Death||Research Area|Cancer|Transcription Factors||Research Area|Cell Biology|Cellular Chaperones
  • Smiles: O=C(NC1=CC=C(C([N+]([O-])=O)=C1)Cl)NC2=CC=C(C=C2)F
  • Inchikey: DWVIOMKFHSRQQM-UHFFFAOYSA-N
  • Cas Number: 897326-30-6
  • Formulation: A solid
  • Storage Temp: -20
  • Shipping Temp: -20
  • Formula Markup: C13H9ClFN3O3
  • Formula Weight: 309.7
  • Shelf Life Days: 1460

DESCRIPTION

An Hsf1 inhibitor; binds to the DNA-binding domain of Hsf1 (Kd = 160 nM); inhibits heat-induced increases in Hsp27 and Hsp70 levels in MEFs at 10 µM; decreases nuclear but not cytoplasmic levels of Hsf1 in C4-2 cells, an effect that can be blocked by MG132; decreases the viability of 22Rv1, C4-2, and PC3 cells (EC50 = 1.6, 1.2, and 3 µM, respectively) and induces cell cycle arrest at the G1 phase in C4-2 cells; induces tumor regression in a TRAMP-C2 murine prostate cancer model at 5 mg/kg