Polyclonal antibody to NLRP1/NALP1 (NAC-alpha)

DESCRIPTION

This antibody recognizes NALP1; human NALP1 is a 1473 amino acid protein, NALP1 (also known as NACHT, LRR and PYD containing protein 1) is a member of NALP CLR subfamily, has an N-terminal pyrin domain (PYD), followed by an NBD, LRR, and a C-terminal CARD domain. NALP1 is a component of both the inflammasome and apoptosome, suggesting that NALP1 has important roles in both inflammation and apoptosis.However, multiple splice variants encoding distinct NALP1 isoforms with varying amino acid lengths have been described and thus the molecular weight detected may vary depending on the isoform(s) expressed.

DETAILS

Gene: NLRP1
App Id: IP,IHC,WB
Antigen: NLRP1/NALP1 (NAC-alpha)
Gene Id: 22861
Isotype: Rabbit IgG
Format Id: Sera
Uniprot Id: Q9C000
Host Animal: Rabbit
Clonality Id: Polyclonal
Reactivity Id: Human
Product Content: 50 µl sera
Alternative Name: NLRP1||CARD7||DEFCAP||KIAA0926||NAC||NALP1
Application Note: WB: 1:1000-1:2000, IHC (paraffin): 1:1000-1:5000, IHC (frozen): Users should optimize, IP: 1:50-1:200
Storage Condition: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Immunogen Information: A synthetic peptide of human NALP1 (NAC/CARD7) (amino acids 1058-1077 CVPSPASQGDLHTKPLGTDD) was used as immunogen for this antibody