Skip to Main Content
More Intelligent Procurement, Faster R&D

Go to Main Navigation

Z03133-50

Scientist.com Supplier

TWEAK, Human

GenScript

DESCRIPTION

TWEAK, short for TNF-related weak inducer of apoptosis, is also known as TNFSF12 and DR3LG. It is a type II transmembrane protein belonging to the TNF superfamily. It is expressed widely in many tissues, such as the heart, skeletal muscle, spleen and peripheral blood. Binding of TWEAK to its receptor TWEAKR induces NF-κB activation, chemokine secretion and apoptosis in certain cell types. TWEAK has also been reported to promote endothelial cell proliferation and migration, thus serving as a regulator of angiogenesis.

DETAILS

  • Form: Lyophilized
  • Purity: > 95% as analyzed by SDS-PAGE> 95% as analyzed by HPLC
  • Species: Human
  • Product Line: Cytokines
  • Expression System: CHO
  • Storage Stability: Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.
  • Biological Activity: ED50 < 1.0 ng/ml, measured in a cell cytotoxicity assay using HTB-38 (HT-29) cells.
  • Protein Construction: TWEAK (Arg99-His249)\nAccession # Q4ACW9