mouse monoclonal IgG2a; HSV-1/2 gD Antibody (H170) is an IgG2a mouse monoclonal HSV-1/2 gD antibody that detects gD, also designated glycoprotein D, of HSV-1 and HSV-2 origin by WB and IF. HSV-1/2 gD Antibody (H170) is available as the non-conjugated anti-HSV-1/2 gD antibody form. Membrane fusion is crucial for the entry, spread and formation of enveloped viruses, such as herpes simplex virus and is mediated by envelope glycoproteins. Two serotypes of the herpes simplex virus, HSV-1 (also known as type 1 or oral) and HSV-2 (type 2 or genital), have been shown to encode at least ten glycoproteins, four of which are necessary and sufficient to facilitate fusion. These four glycoproteins include glycoprotein B (gB), glycoprotein D (gD), glycoprotein H (gH) and glycoprotein L (gL). The fusion event is dependent upon the expression of a gD receptor on target cell membranes and does not require the presence of cell-surface glycosaminoglycans. HSV-1/2 gD (glycoprotein D) specifically allows a stable connection to cellular receptors. Late adsorption to host cell membranes is correlated to a conformation change of gD occurring after receptor binding, followed by interaction of gD with the gH/gL heterodimer.