mouse monoclonal IgG2b; Neurogenin 3 Antibody (C-7) is an IgG2b κ mouse monoclonal Neurogenin 3 antibody (also designated NGN3 antibody, BHLHa7 antibody, Class A Basic Helix-Loop-Helix Protein 7 antibody, Protein Atonal Homolog 5 antibody, Neurogenin-3 antibody, Math4B antibody, NGN-3 antibody, BHLHA7 antibody, or ATOH5 antibody) that detects the Neurogenin 3 protein of mouse and rat origin by WB, IP, IF and ELISA. Neurogenin 3 Antibody (C-7) is available as both the non-conjugated anti-Neurogenin 3 antibody form, as well as multiple conjugated forms of anti-Neurogenin 3 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The neurogenin family of proteins belongs to the basic helix-loop-helix (bHLH) superfamily and consists of Neurogenin 1, Neurogenin 2 and Neurogenin 3 (also designated ngn3). bHLH members are transcriptional regulators that determine cell fate. Neurogenin 3 is expressed in discrete regions of developing neurons and in the embryonic pancreatic islets of Langerhans. HNF-6 (hepatocyte nuclear factor 6) acts as a positive regulator of Neurogenin 3 by binding to and stimulating the nuerogenin gene promoter. Neurogenin 3 is involved in the intial differentiation of the four islets cell types, while a network of transcription factors, including Hlxb9, Isl1, Neuro D, Nkx-2.2, Nkx-6.4, Pax-4, Pax-6, PDX-1 and Mash1, are required for final differentiation. Neurogenin 3 acts upstream of Neuro D in a bHLH cascade. Neurogenin 3 activates the expression of Neuro D at the onset of islet cell differentiation through box sequences E1 and E3 in the Neuro D promoter.