APLNR Antibody (Center) Blocking peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 187
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: APLNR
Other Names: Apelin receptor, Angiotensin receptor-like 1, G-protein coupled receptor APJ, G-protein coupled receptor HG11, APLNR, AGTRL1, APJ
Availability: 2 weeks
Bio Background: This gene encodes a member of the G protein-coupledreceptor gene family. The encoded protein is related to theangiotensin receptor, but is actually an apelin receptor thatinhibits adenylate cyclase activity and plays a counter-regulatoryrole against the pressure action of angiotensin II by exertinghypertensive effect. It functions in the cardiovascular and centralnervous systems, in glucose metabolism, in embryonic and tumorangiogenesis and as a human immunodeficiency virus (HIV-1)coreceptor. Two transcript variants resulting from alternativesplicing have been identified.
Bio References: Tao, Y., et al. Invest. Ophthalmol. Vis. Sci. 51(8):4237-4242(2010)Zhao, Q., et al. Am. J. Hypertens. 23(6):606-613(2010)Lee, D.K., et al. Biochem. Biophys. Res. Commun. 395(2):185-189(2010)Falcao-Pires, I., et al. Expert Opin. Ther. Targets 14(3):231-241(2010)Peltonen, T., et al. J. Heart Valve Dis. 18(6):644-652(2009)
Primary Accession: P35414
Targetspecificity: The synthetic peptide sequence used to generate the antibody AP14123c was selected from the Center region of APLNR. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.