GPI8 Antibody (N-term) Blocking Peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 10026
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: PIGK
Other Names: GPI-anchor transamidase, GPI transamidase, 3---, GPI8 homolog, hGPI8, Phosphatidylinositol-glycan biosynthesis class K protein, PIG-K, PIGK, GPI8
Availability: 2 weeks
Bio Background: GPI8 is a member of the cysteine protease family C13 that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This protein is a member of the multisubunit enzyme, GPI transamidase and is thought to be its enzymatic component. GPI transamidase mediates GPI anchoring in the endoplasmic reticulum, by catalyzing the transfer of fully assembled GPI units to proteins.
Bio References: Ohishi, K., et al., J. Biol. Chem. 278(16):13959-13967 (2003).Vainauskas, S., et al., J. Biol. Chem. 277(34):30535-30542 (2002).Ohishi, K., et al., EMBO J. 20(15):4088-4098 (2001).Meyer, U., et al., Biochemistry 39(12):3461-3471 (2000).Yu, J., et al., Proc. Natl. Acad. Sci. U.S.A. 94(23):12580-12585 (1997).
Other Accession: GPI8_HUMAN
Primary Accession: Q92643
Targetspecificity: The synthetic peptide sequence used to generate the antibody AP2462a was selected from the N-term region of human GPI8 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.