DESCRIPTION

• Target: NaVbeta3
• Gene Id: 245956
• Isotype: IgG2B
• Conjugate: PerCP
• Immunogen: Fusion protein amino acids 1-215 (full-length) of rat NavBeta3
• References: 1. Genes and mapped phenotypes. (n.d.). Retrieved March 26, 2015, from http://www.ncbi.nlm.nih.gov/gene/?term=Q9jK00 2. Qu Y., et al. (2001) Mol Cell Neurosci. 18(5): 570-580. 3. Ishikawa T., et al. (2013) Circ J. 77(4): 956-967.
• Swiss-prot: Q9JK00
• Specificity: Detects ~40kDa. Does not cross-reat with NavBeta1, Navbeta2, or Navbeta4.
• Applications: WB | ICC/IF
• Clone Number: N396/29 (Formerly sold as S396-29)
• Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
• Host Species: Mouse
• Product Type: Monoclonal
• Purification: Protein G Purified
• Concentration: 1 mg/ml
• Research Areas: Neuroscience | Ion Channels | Sodium Channels | Voltage-Gated Sodium Channels
• Storage Buffer: PBS pH7.4, 50% glycerol, 0.1% sodium azide *Storage buffer may change when conjugated
• Accession Number: NP_620797.1
• Alternative Names: Sodium channel subunit beta-3 Antibody, Scn3b Antibody, KIAA1158 Antibody
• Antibody Dilution: WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
• Cite This Product: StressMarq Biosciences Cat# SMC-490D-PCP, RRID: AB_2702546
• Immunogen Species: Rat
• Storage Temperature: Conjugated antibodies should be stored according to the product label
• Shipping Temperature: Blue Ice or 4ºC
• Cellular Localization: Membrane
• Scientific Background: Nav Beta 3 (SCN3B) belongs to the voltage-gated sodium channel group, and modulates channel gating kinetics. It inactivates the sodium channel opening more slowly than its Beta1 subunit. It is also unique in causing persistent sodium currents which are thought to amplify summation of synaptic imputs which is likely to increase the excitability of specific neurons to their individual inputs (2). Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons (1, 2). Defects in SCN3B are the cause of Brugada syndrome (3).
• Certificate of Analysis: A 1:100 dilution of SMC-490 was sufficient for detection of NavBeta3 in 20 µg of mouse brain lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
• Species Reactivity Full Name: Human | Mouse | Rat