RP01430
Recombinant Human Guanylyl cyclase C/GUCY2C Protein
ABclonal
Image
Image
DESCRIPTION
GUCY2C (Guanylyl Cyclase C), also known as heat-stable enterotoxin receptor, is a type I transmembrane protein of the guanylate cyclase (gc) family that signal by producing cGMP. Guanylate cyclase C (GUCY2C) and its hormones guanylin and uroguanylin have recently emerged as one paracrine axis defending intestinal mucosal integrity against mutational, chemical, and inflammatory injury. GUCY2C murine CAR-T cells recognized and killed human colorectal cancer cells endogenously expressing GUCY2C. Thus, we have identified a human GUCY2C-specific CAR-T cell therapy approach that may be developed for the treatment of GUCY2C-expressing metastatic colorectal cancer. GUCY2C may represent a new target for anti-obesity pharmacotherapy.
DETAILS
- Tag: C-His&Avi
- Source: HEK293 cells
- Gene Id: 2984
- Species: Human
- Lead Time: 3-5 weekdays
- Swiss Prot: P25092-1
- Research Areas: Biosimilar Drug Targets
- Alternative Names: GUCY2C,DIAR6,GC-C,GUC2C,MECIL,MUCIL,STAR
Equivalent Items
| ... Loading