RP00153
Recombinant Human Activin RIIB/ACVR2B Protein
ABclonal
DESCRIPTION
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor.
DETAILS
- Tag: C-hFc&His
- Source: HEK293 cells
- Gene Id: 93
- Species: Human
- Lead Time: 3-5 weekdays
- Swiss Prot: Q13705
- Research Areas: Cytokines & Cytokine receptors
- Alternative Names: ACVR2B,ACTRIIB,ActR-IIB,HTX4
Equivalent Items
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