30-2635
Anti-Human CD172a PE (Clone : 15-414)
Abeomics
DESCRIPTION
CD172a, the signal-regulatory protein alpha (SIRP alpha), also known as SH2 domain-containing phosphatase substrate-1 (SHPS1), is a 75-110 kDa transmembrane glycoprotein expressed mainly on granulocytes, monocytes, macrophages, dendritic cells and neurons. Its extracellular ligand is CD47. CD172a serves as a substrate of activated receptor tyrosine kinases and upon phosphorylation it recruits SH2 domain-containing tyrosine phosphatases, thereby regulating signal transduction processes related to cell activation, transmigration and phagocytosis. CD172a is a specific marker of cardiomyocytes derived from human pluripotent stem cells and serves as a negative regulator of signaling and growth in myeloid progenitor cells.Specificity : The mouse monoclonal antibody 15-414 recognizes en extracellular epitope of CD172a (SIRP alpha), an approximately 90 kDa transmembrane glycoprotein expressed on cells of myeloid origin and neurons.
DETAILS
- Gene: SIRPA
- App Id: FACS
- Antigen: CD172a
- Gene Id: 140885
- Isotype: Mouse IgG2a
- Clone Name: 15-414
- Clonality Id: Monoclonal
- Conjugate Id: PE
- Purification: The purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography.
- Reactivity Id: Human
- Product Content: Formulation : Stabilizing phosphate buffered saline (PBS) solution containing 15 mM sodium azide
- Alternative Name: PTPNS1, BIT, MFR, SIRPA, SHPS1,signal regulatory protein alpha
- Application Note: Flow cytometry: The reagent is designed for analysis of human blood cells using 10 µl reagent / 100 µl of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
- Storage Condition: Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light.
- Immunogen Information: Kg-1a cell line
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