DESCRIPTION

• Mw: 49.64 kDa
• Tag: mGFP
• Accn: NM_001122659
• Type: Human Tagged ORF Clone Lentiviral Particle
• Refseq: NM_001122659.1
• Status: 7 Weeks*
• Symbol: Endothelin B Receptor
• Vector: pLenti-C-mGFP-P2A-Puro
• Category: cDNA Clones
• Locus Id: 1910
• Orf Size: 1326 bp
• Synonyms: ABCDS; ET-B; ET-BR; ETB; ETB1; ETBR; ETRB; HSCR; HSCR2; WS4A
• Refseq Orf: 1329 bp
• Uniprot Id: P24530
• Availability: 7 Weeks
• Cytogenetics: 13q22.3
• Gene Summary: The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Oct 2016]
• Sequence Data: ORF Nucleotide Sequence ( show hide ) The ORF insert of this clone is exactly the same as(RC225723).
• Oti Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Oti Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• Protein Families: Druggable Genome, GPCR, Transmembrane
• Protein Pathways: Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction
• Mammalian Cell Selection: Puromycin