mouse monoclonal IgG1; CYP1A1 Antibody (A-9) is an IgG1 κ mouse monoclonal CYP1A1 antibody (also designated Cytochrome P450 1A1 antibody) that detects the CYP1A1 protein of mouse, rat and human origin by WB, IP, IF and ELISA. CYP1A1 Antibody (A-9) is available as both the non-conjugated anti-CYP1A1 antibody form, as well as multiple conjugated forms of anti-CYP1A1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. P450 enzymes constitute a family of monooxygenase enzymes that are involved in the metabolism of a wide array of endogenous and xenobiotic compounds. Several P450 enzymes have been classified by sequence similarities as members of the CYP1A and CYP2A subfamilies. NADPH cytochrome P450 reductase is a microsomal enzyme responsible for the transfer of electrons from NADPH to cytochrome P450 enzymes during the P450 catalytic cycle. NADPH cytochrome P450 reductase is localized to the endoplasmic reticulum where it is also able to transfer electrons to heme oxygenase and cytochrome b5. NADPH cytochrome P450 reductase is structurally related to two separate flavoprotein families, ferredoxin nucleotide reductase (FNR) and flavodoxin. Electron transfer of NADPH cytochrome P450 reductase requires the binding of two flavin cofactors, FAD and FMN, to the FNR and flavodoxin domains, respectively.