mouse monoclonal IgG1; TH-POK Antibody (A-4) is an IgG1 κ mouse monoclonal TH-POK antibody (also designated TH-POK antibody) that detects the TH-POK protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. TH-POK Antibody (A-4) is available as both the non-conjugated anti-TH-POK antibody form, as well as multiple conjugated forms of anti-TH-POK antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. TH-POK (T-helper-inducing POZ/Krüppel-like factor), also known as zinc finger protein 67 (ZFP67), zinc finger and BTB domain-containing protein 7B or Krüppel-related zinc finger protein cKrox, is a 539 amino acid protein that contains one BTB (POZ) domain and four C2H2-type zinc fingers. Localized to the nucleus, TH-POK functions primarily as a key regulator of lineage commitment of immature T-cell precursors. Specifically, the presence of TH-POK directs positively selected thymocytes to the CD4 lineage, whereas its absence causes default development to the CD8 lineage. TH-POK also functions as a transcriptional repressor of various other genes, such as COL1A1, COL1A2 and fibronectin.