12-1217-20 12-1217
Anti-MUC18 / CD146 / MCAM (Melanoma Cell Adhesion Molecule) Recombinant Mouse Monoclonal Antibody (Clone:rMUC18/1130)
Abeomics
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DESCRIPTION
Mel-CAM belongs to the immunoglobulin superfamily and functions as a Ca2+-independent cell adhesion molecule. Mel-CAM expression is restricted to advanced primary and metastatic melanomas and to cell lines of the neuroectodermal lineage, but not normal melanocytes. Mel-CAM is found on 80% of advanced primary human melanomas and correlates well with development of metastatic disease.
DETAILS
- Gene: MCAM
- App Id: IHC
- Gene Id: 4162
- Isotype: Mouse IgG1, kappa
- Format Id: Purified
- Clone Name: rMUC18/1130
- Uniprot Id: P43121
- Host Animal: Mouse
- Clonality Id: Monoclonal
- Purification: Protein A/G
- Reactivity Id: Human
- Product Content: 200µg/ml of recombinant MAb purified by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
- Alternative Name: Cell Surface Glycoprotein MUC18, Cell Surface Glycoprotein P1H12, Gicerin, Melanoma Adhesion Molecule (MCAM), Melanoma Associated Glycoprotein MUC18, Melanoma Cell Adhesion Molecule, Melanoma-associated Antigen A32, Mel-CAM, S-endo 1 Endothelial-associated Antigen.
- Application Note: Immunohistochemistry (Formalin-fixed) (1-2µg/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 1mM EDTA, pH 8.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
- Storage Condition: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.
- Immunogen Information: Recombinant full-length human MUC18 protein