LA1-M5254-100ug LA1-M5254-1mg
Mouse LAIR1 / CD305 Protein, Mouse IgG2a Fc Tag, low endotoxin
ACROBiosystems
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DESCRIPTION
Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is constitutively expressed on the majority of human peripheral blood mononuclear leukocytes. LAIR-1 or CD305 is a transmembrane glycoprotein with a single immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory motifs. LAIR-1 recruits SHP-1 and SHP-2 phosphatases upon activation, and cross-linking of the LAIR-1 antigen on natural killer (NK) cells results in strong inhibition of NK cell–mediated cytotoxicity.
Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation.Diseases associated with LAIR1 include Chronic Active Epstein-Barr Virus Infection and Palindromic Rheumatism.
DETAILS
- Tag: C-mFc(mIgG2a)
- Host: HEK293
- Size: 100ug
- Buffer: 50 mM Tris, 100 mM Glycine, pH7.5
- Format: Powder
- Purity: 95%
- Source: Mouse LAIR1 Protein, Mouse IgG2a Fc Tag (LA1-M5254) is expressed from human 293 cells (HEK293). It contains AA Gln 22 - Tyr 141 (Accession # Q8BG84-1).
- Storage: -20℃
- Category: Immune Checkpoint Proteins
- Molecule: LAIR-1
- Accession: NP_001106945.1
- Conjugate: Unconjugated
- Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
- Exp Region: Gln 22 - Tyr 141
- Swiss-prot: Q8BG84-1
- Package Size: 100ug*1
- Characteristics: This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 40.6 kDa. The protein migrates as 50-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
- Endotoxin Level: 0.1 EU per μg
- Molecular Weight: 40.6 kDa
- Shipping Condition: RT
- Species Reactivity: Mouse
- Extra Shippinghandling Fee: Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/A48-Shipping-and-Payments.html