RP01852
Recombinant Mouse Autotaxin/E-NPP2 Protein
ABclonal
Image
DESCRIPTION
ENPP-2, also known as Autotaxin, belongs to the ectonucleotide pyrophosphatase/phosphodiesterase (NPP) family. Some NPPs hydrolyze phosphates from nucleotides and their derivatives. ENPP-2 shares 40 - 50% identity to ENPP1 & 3, all of which contain a N-terminal intracellular domain, a single transmembrane domain and a large extracellular domain that includes a catalytic domain, two somatomedin-B-like domains, and a C-terminal nuclease-like domain . Unlike ENPP-1 and ENPP-3, ENPP-2 has weak activity against nucleotides, but exhibits a lysophospholipase D activity which allows the formation of lysophosphatidic acid (LPA) and choline from lysophosphatidylcholine . The hydrolysis of nucleotides and lysophospholipids by ENPP-2 is mediated by a single catalytic site . Evidence shows LPA and sphingosine 1-phosphate to be specific inhibitors of ENPP-2 . ENPP-2 was originally found to stimulate tumor cell motility and has since been found to enhance tumor invasion and metastasis ( and to be up-regulated in several types of carcinomas including breast and lung .
DETAILS
- Tag: C-His
- Source: HEK293 cells
- Gene Id: 18606
- Species: Mouse
- Lead Time: 3-5 weekdays
- Swiss Prot: Q9R1E6-1
- Research Areas: Cytokines & Cytokine receptors
- Alternative Names: Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, E-NPP 2, 3.1.4.39, Autotaxin, Extracellular lysophospholipase D, LysoPLD,Enpp2, Npps2, Pdnp2
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