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SPD-C5258-100ug SPD-C5258-1mg

SARS-CoV-2 S protein RBD (K417T, E484K, N501Y), Fc Tag (MALS verified)

ACROBiosystems

DESCRIPTION

It's been reported that Coronavirus can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.

DETAILS

  • Tag: C-Fc
  • Host: HEK293
  • Size: 100ug
  • Buffer: 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
  • Format: Powder
  • Purity: 95%
  • Source: SARS-CoV-2 S protein RBD (K417T,E484K,N501Y), Fc Tag (SPD-C5258) is expressed from human 293 cells (HEK293). It contains AA Arg 319 - Lys 537 (Accession # QHD43416.1 (K417T, E484K, N501Y)). The K417T, E484K, N501Y mutations were identified in the SARS-CoV-2 Gamma variant (Pango lineage: P.1; other names: 20J/501Y.V3).
  • Storage: -20℃
  • Category: Viral Proteins
  • Molecule: Spike RBD
  • Accession: QHD43416.1 (K417T, E484K, N501Y)
  • Conjugate: Unconjugated
  • Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
  • Exp Region: Arg 319 - Lys 537
  • Package Size: 100ug*1
  • Characteristics: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 51.1 kDa. The protein migrates as 55-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
  • Endotoxin Level: 1.0 EU per μg
  • Molecular Weight: 51.1 kDa
  • Shipping Condition: RT
  • Species Reactivity: SARS-CoV-2
  • Extra Shippinghandling Fee: Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/A48-Shipping-and-Payments.html