Anti-CD10 (Membrane Metalloendopeptidase) Monoclonal Antibody(Clone: 56C6)

DESCRIPTION

Recognizes a 100kDa glycoprotein, identified as CD10, also known as Common Acute Lymphocytic Leukemia Antigen (CALLA). It is a cell surface enzyme with neutral metalloendopeptidase activity, which inactivates a variety of biologically active peptides. CD10 is expressed on the cells of lymphoblastic, Burkitt's, and follicular germinal center lymphomas, and on cells from patients with chronic myelocytic leukemia (CML). It is also expressed on the surface of normal early lymphoid progenitor cells, immature B cells within adult bone marrow and germinal center B cells within lymphoid tissue. CD10 is also present on breast myoepithelial cells, bile canaliculi, fibroblasts, with especially high expression on the brush border of kidney and gut epithelial cells.

DETAILS

Gene: MME
App Id: IHC
Gene Id: 4311
Isotype: Mouse IgG1, kappa
Clone Name: 56C6
Uniprot Id: P08473
Host Animal: Mouse
Clonality Id: Monoclonal
Reactivity Id: Human
Product Content: Tissue culture supernatant with 0.05% Azide. Contact us if you require it in a different format.
Alternative Name: Atriopeptidase; Common acute lymphocytic leukemia antigen (CALLA); Enkephalinase (EPN); gp100; Membrane metalloendopeptidase (MME); Neprilysin; Neutral endopeptidase (NEP); Skin fibroblast elastase (SFE)
Application Note: Immunohistochemistry (Formalin-fixed) (1:50-1:100 for 30 minutes at RT) (Staining of formalin-fixed tissues requires heating tissue sections in 1mM EDTA, pH 9.0, for 45 min at 95&degC followed by cooling at RT for 20 minutes)
Storage Condition: Store at 2 to 8°C. Antibody is stable for 24 months. Non-hazardous.
Immunogen Information: Recombinant human CD10 protein fragment