DESCRIPTION

• Target: HCN1
• Gene Id: 84390
• Isotype: IgG1
• Conjugate: ATTO 594
• Immunogen: Fusion protein amino acids 778-910 (C terminus) of rat HCN1
• References: 1. Zong X., et al. (2005) J Biol Chem. 280(40): 34224-34232.
• Swiss-prot: Q9JKB0
• Specificity: Detects ~100kDa. No cross-reactivity against HCN2.
• Applications: WB | IHC | IP | AM
• Clone Number: S70
• Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
• Host Species: Mouse
• Product Type: Monoclonal
• Purification: Protein G Purified
• Concentration: 1 mg/ml
• Research Areas: Neuroscience | Ion Channels | Cyclic Nucleotide-Gated Ion Channels | cardiovascular System | Heart
• Storage Buffer: PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
• Accession Number: NP_445827.1
• Alternative Names: BCNG-1 Antibody, BCNG1 Antibody, Brain cyclic nucleotide gated channel 1 Antibody, Brain cyclic nucleotide-gated channel 1 Antibody, HAC2 Antibody, HCN1 Antibody, HCN1_HUMAN Antibody, Hyperpolarization activated cyclic nucleotide gated potassium channel 1 Antibody, Potassium/sodium hyperpolarization activated cyclic nucleotide gated channel 1 Antibody, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 Antibody
• Antibody Dilution: WB (1:1000), IHC (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
• Cite This Product: StressMarq Biosciences Cat# SMC-304D-A594, RRID: AB_2700077
• Immunogen Species: Rat
• Storage Temperature: Conjugated antibodies should be stored according to the product label
• Shipping Temperature: Blue Ice or 4ºC
• Cellular Localization: Membrane
• Scientific Background: Hyperpolarization-activated cation channels of the HCN gene family, such as HCN1, play a crucial role in the regulatons of cell excitability. Importantly, they contribute to spontaneous rhythmic activity in both the heart and brain (1).
• Certificate of Analysis: 1 µg/ml of SMC-304 was sufficient for detection of HCN1 in 10 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
• Species Reactivity Full Name: Human | Mouse | Rat