Anti-Human CD340 FITC (Clone : 24D2)

DESCRIPTION

The oncoprotein ErbB2/HER2 (human epidermal growth factor receptor 2), also known as Neu or CD340, is a 185 kDa transmembrane tyrosine kinase of cell surface growth factor receptor family. It is present in a wide variety cell types of normal human fetal and adult tissues and is frequently overexpressed in human carcinomas (e.g. in 20-30% cases of breast cancer cells). Activation of ErbB2 triggers intracellular signalling events, which are essential for cell growth and differentiation. In the last 20 years ErbB2 antigen has become very important marker and therapy target in patient care.Specificity : The mouse monoclonal antibody 24D2 recognizes an extracellular epitope of human CD340 (HER-2), a type I transmembrane protein expressed by mesenchymal stem cells, B-lymphoblastic leukemia cells, subsets of C-ALL blasts, and and various types of carcinomas.

DETAILS

Gene: ERBB2
App Id: FACS
Antigen: CD340
Gene Id: 2064
Isotype: Mouse IgG1
Clone Name: 24D2
Clonality Id: Monoclonal
Conjugate Id: FITC
Purification: The purified antibody is conjugated with fluorescein isothiocyanate (FITC) under optimum conditions. The conjugate is purified by size-exclusion chromatography.
Reactivity Id: Human
Product Content: Formulation : Stabilizing phosphate buffered saline (PBS) solution containing 15 mM sodium azide
Alternative Name: ERBB2, NEU, NGL, HER2, TKR1, MLN 19,erb-b2 receptor tyrosine kinase 2
Application Note: Flow cytometry: The reagent is designed for analysis of human blood cells using 4 µl reagent / 100 µl of whole blood or 106 cells in a suspension. The content of a vial (0.4 ml) is sufficient for 100 tests.
Storage Condition: Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light.
Immunogen Information: NIH-3T3/huCD340 cells