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Recombinant Human TSLP



TSLP is a hemopoietic protein that is expressed in the heart, liver and prostate. TSLP overlaps biological activities with IL-7, and binds with the heterodimeric receptor complex consisting of the IL-7R alpha-chain (IL-7Ralpha) and the TSLP-specific chain (TSLPR). Like IL-7, TSLP induces phosphorylation of STAT3 and STAT5, but uses kinases other than the JAKs for activation. TSLP prohibits apoptosis and stimulates growth of the human acute myeloid leukemia (AML)-derived cell line MUTZ3. It induces the release of T cell-attracting chemokines TARC and MDC from monocytes, and activates CD11c(+) dendritic cells (DCs). TSLP-activated DCs have been shown to prime naive T cells to produce the proallergic cytokines (IL-4, IL-5, IL-13, TNF-alpha) while down-regulating IL-10 and IFN-gamma, suggesting a role in initiating allergic inflammation. Recombinant Human TSLP is a 15.0 kDa protein consisting of 132 amino acid residues.


  • Gene Id: 85480
  • Uniprot: Q969D9
  • Activity: Not available.
  • Category: RUO Cytokines
  • Subcategory: Growth Factors & Cytokines
  • Research Areas: Apoptosis, Immune System, Inflammation
  • Alternative Names: Thymic Stromal Lymphopoietin
  • Species of Origin: Human
  • Expression System Source: E.coli