5039598-25mg 5039598-10mg
NU 7441
Biogems
DESCRIPTION
NU 7441 is a selective and potent DNA-PK inhibitor (IC50 14nM) and P13K inhibitor (IC50 5uM). It is reported enhance the cytotoxic effects of radiation in cancer cell lines and potentiate the effects of etoposide and doxorubicin. NU 7441 is also reported to enhance the efficiency of CRISPR-Cas9 mediated homology-directed repair (HDR) 2 to 4 fold and decrease nonhomologous end-joining (NHEJ) frequency by 2 fold.
DETAILS
- Purity: ≥98%
- Synonyms: KU57788, KU 57788, NU-7441, NU7441
- Cas Number: 503468-95-9
- References: Robert, F., Barbeau, M., Éthier, S., Dostie, J., & Pelletier, J. (2015). Pharmacological inhibition of DNA-PK stimulates Cas9-mediated genome editing. Genome medicine, 7(1), 93. Spagnolo, L., Barbeau, J., Curtin, N. J., Morris, E. P., & Pearl, L. H. (2012). Visualization of a DNA-PK/PARP1 complex. Nucleic acids research, 40(9), 4168-4177. Zhao, Y., Thomas, H. D., Batey, M. A., Cowell, I. G., Richardson, C. J., Griffin, R. J., ... & Curtin, N. J. (2006). Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441. Cancer research, 66(10), 5354-5362.
- Application: FA
- Formulation: Crystalline solid
- Chemical Name: 8-dibenzothiophen-4-yl-2-morpholin-4-ylchromen-4-one
- Molecular Weight: 413.5
- Molecular Formula: C25H19NO3S
- Storage Conditions: Product should be kept at -20°C.
- Pubchem Openeye Can Smiles: C1COCCN1C2=CC(=O)C3=C(O2)C(=CC=C3)C4=CC=CC5=C4SC6=CC=CC=C56