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E6310Hu

Human Transmembrane Channel-like Protein 1, TMC1 ELISA Kit

Bioassay Technology Laboratory

DESCRIPTION

Transmembrane channel-like protein 1 is a protein that in humans is encoded by the TMC1 gene. TMC1 contains six transmembrane domains with both the C and N termini on the endoplasmic side of the membrane, as well as a large loop between domains 4 and 5. This topology is similar to that of transient receptor potential channels (TRPs), a family of proteins involved in the perception of senses such as temperature, taste, pressure, and vision. TMC1 has been located in the post-natal mouse cochlea, and knockouts for TMC1 and TMC2 result in both auditory and vestibular deficits (hearing loss and balance issues) indicating TMC1 is a molecular part of auditory transduction.

DETAILS

  • Gene Id: 117531
  • Uniprot: Q8TDI8
  • Lead Time: 3 days
  • Assay Type: Sandwich
  • Sample Type: Serum, plasma, cell culture supernates
  • Sensitivity: 7.43ng/L
  • Detection Range: 15-3000ng/L
  • Detection Method: ELISA
  • Species Reactivity: Human