mouse monoclonal IgG1; OATP-C Antibody (A-3) is an IgG1 κ mouse monoclonal OATP-C antibody (also designated SO1B1 antibody, Solute Carrier Organic Anion Transporter Family Member 1B1 antibody, OATP1B1 antibody, LST-1 antibody, Liver-Specific Organic Anion Transporter 1 antibody, SLC21A6 antibody, OATP-2 antibody, OATP2 antibody, OATPC antibody, LST1 antibody, Solute Carrier Organic Anion Transporter Family Member 1B1 antibody, or Solute Carrier Family 21 Member 6 antibody) that detects the OATP-C protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. OATP-C Antibody (A-3) is available as both the non-conjugated anti-OATP-C antibody form, as well as multiple conjugated forms of anti-OATP-C antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The organic anion transporting polypeptides, OATP-A (also designated OATP1, OATP1A2 and SLC21A3) and OATP-C (also designated OATP2, SLC21A6 and LST1), mediate hepatic uptake of cardiac glycosides. The expression of OATP-C, but not OATP-A, is inducible by phenobarbital and pregnenolone-16a-carbonitrile, resulting in the increased capacity of the liver to extract cardiac glycosides from the plasma. OATP-A is expressed in liver and kidney and helps mediate sodium-independent uptake of the anionic steroid conjugates dehydroepiandrosterone sulfate, estradiol-17-glucuronide and prostaglandin. OATP-C is exclusively expressed in liver and is localized to the basolateral hepatocyte membrane. Although OATP-C mRNA levels decrease during pregnancy and increase postpartum, OATP-C protein levels remain relatively constant. OATP-C transports taurocholic acid, the adrenal androgen dehydroepiandroserone sulfate, thyroid hormone, hydroxymethylglutaryl-CoA reductase inhibitor and pravastatin. OATP-C is therefore a novel organic anion transport protein that has overlapping but not identical substrate specificities with other subtypes of OATP. OATP-A and OATP-C are both pravastatin transporters, suggesting that they are responsible for the hepatic uptake of the liver-specific hydroxymethylglutaryl-CoA reductase inhibitor in mouse, rat and human.

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.