mouse monoclonal IgG1; Slac2-a Antibody (C-3) is an IgG1 λ mouse monoclonal Slac2-a antibody (also designated Slac2-a antibody) that detects the Slac2-a protein of mouse origin by WB, IP, IF and ELISA. Slac2-a Antibody (C-3) is available as both the non-conjugated anti-Slac2-a antibody form, as well as multiple conjugated forms of anti-Slac2-a antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Slac2-a (for synaptotagmin-like protein (Slp) homolog lacking C2 domains-a) links Rab27A on melanosomes with Myosin VA in melanocytes. Slac2-a binds Myosin VA through a C-terminal region and GTP-bound Rab27A through its synaptotagmin-like protein homology domain (SHD), which is located near the N-terminus. The transport of pigment and cytotoxic granules in melanocytes requires the stable formation of this complex, and thus mutations in the binding domains of the three protein components may cause albinism and/or severe immune disorders.

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.