DESCRIPTION

• Target: mGluR5
• Gene Id: 24418
• Isotype: IgG1
• Conjugate: ATTO 488
• Immunogen: Fusion protein amino acids 824-1203 (cytoplasmic C-terminus) of rat mGluR5b
• References: 1. Mayer M.L. (2005) Current Opinion in Neurobio. 15(3): 282-288. 2. Keinane K., et al. (1990) Science. 249: 556-560.
• Swiss-prot: P31424
• Specificity: Detects ~130kDa (both mGluR1 and mGluR5).
• Applications: WB | IHC | ICC/IF | IP
• Clone Number: N75/33 (Formerly sold as S75-33)
• Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
• Host Species: Mouse
• Product Type: Monoclonal
• Purification: Protein G Purified
• Concentration: 1 mg/ml
• Research Areas: Neuroscience | Neurotransmitter Receptors | Glutamate Receptors | Metabotropic Glutamate Receptors (mGluR) | Cell Signaling | Cancer
• Storage Buffer: PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
• Accession Number: NP_058708.1
• Alternative Names: Glutamate receptor metabotropic 5,GPRC1E Antibody, GRM 5 Antibody, GRM5 Antibody, Metabotropic glutamate receptor 5 Antibody, Metabotropic glutamate receptor 5 variant F Antibody, Metabotropic glutamate receptor 5 variant G Antibody, Metabotropic glutamate receptor 5 variant H Antibody, mGlu5 Antibody, mGluR5 Antibody, mGluR5a Antibody, mGluR5b Antibody, Glutamate receptor metabotropic 1 Antibody, glutamate receptor Antibody, metabotropic 1 Antibody, GPRC1A Antibody, GRM 1 Antibody, GRM1 alpha Antibody, GRM1 Antibody, GRM1_HUMAN Antibody, GRM1A Antibody, Metabotropic glutamate receptor 1 Antibody, mGlu1 Antibody, mGluR1 alpha Antibody, mGluR1 Antibody, mGluR1A Antibody
• Antibody Dilution: WB (1:1000), IHC (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
• Cite This Product: StressMarq Biosciences Cat# SMC-407D-A488, RRID: AB_2701078
• Immunogen Species: Rat
• Storage Temperature: Conjugated antibodies should be stored according to the product label
• Shipping Temperature: Blue Ice or 4ºC
• Cellular Localization: Cell Membrane
• Scientific Background: The AMPA receptor is a non-NMDA-type ionotropic transmembrane receptor for glutamate that mediates fast synaptic transmission in the CNS. AMPARs are composed of four types of subunits, designated as GluR1, GluR2, GluR3 and GluR4, which combine to form tetramers (1,2).
• Certificate of Analysis: 1 µg/ml of SMC-407 was sufficient for detection of mGluR1/5 glutamate receptor in 20 µg of rat brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.
• Species Reactivity Full Name: Human | Mouse | Rat