25-hydroxy Cholesterol

DESCRIPTION

25-hydroxy Cholesterol is a dietary cholesterol derivative with a side chain substituted oxysterol that is capable of triggering the activation of many cholesterol molecules. It has been reported to activate ABCA1 signaling, atherosclerosis modulation, and induces apoptosis in human cell lines through caspases activation and bcl-2 downregulation. 25-hydroxy Cholesterol is immunomodulating and is capable of suppressing macrophage differentiation from monocytes.

DETAILS

Purity: ≥98%
Synonyms: 25-hydroxycholesterol, (3beta)-isomer, 5-cholestene-3beta,25-diol
Cas Number: 2140-46-7
References: Peng, S. K., Taylor, C. B., Hill, J. C., & Morin, R. J. (1985). Cholesterol oxidation derivatives and arterial endothelial damage. Atherosclerosis, 54(2), 121-133. Erickson, S. K., Matsui, S. M., Shrewsbury, M. A., Cooper, A. D., & Gould, R. G. (1978). Effects of 25-hydroxycholesterol on rat hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in vivo, in perfused liver, and in hepatocytes. Journal of Biological Chemistry, 253(12), 4159-4164. Aupeix, K., Weltin, D., Mejia, J. E., Christ, M., Marchal, J., Freyssinet, J. M., & Bischoff, P. (1995). Oxysterol-induced apoptosis in human monocytic cell lines. Immunobiology, 194(4), 415-428.
Application: FA
Formulation: Crystalline solid
Chemical Name: (3S,8S,9S,10R,13R,14S,17R)-17-[(2R)-6-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
Molecular Weight: 402.7
Molecular Formula: C27H46O2
Storage Conditions: Product should be kept at-20°C.
Pubchem Openeye Can Smiles: CC(CCCC(C)(C)O)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C