DESCRIPTION

• Mw: 45.8 kDa
• Tag: Myc-DDK
• Accn: NM_001198530
• Type: Human Tagged ORF Clone Lentiviral Particle
• Refseq: NM_001198530.1, NP_001185459.1
• Status: 7 Weeks*
• Symbol: TCF7L2
• Vector: pLenti-C-Myc-DDK-P2A-Puro
• Category: cDNA Clones
• Locus Id: 6934
• Orf Size: 1224 bp
• Synonyms: TCF-4; TCF4
• Refseq Orf: 1227 bp
• Availability: 7 Weeks
• Cytogenetics: 10q25.2-q25.3
• Gene Summary: This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.[provided by RefSeq, Oct 2010]
• Sequence Data: ORF Nucleotide Sequence ( show hide ) The ORF insert of this clone is exactly the same as(RC231215).
• Oti Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Oti Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• Protein Families: Druggable Genome, Transcription Factors
• Protein Pathways: Acute myeloid leukemia, Adherens junction, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Basal cell carcinoma, Colorectal cancer, Endometrial cancer, Melanogenesis, Pathways in cancer, Prostate cancer, Thyroid cancer, Wnt signaling pathway
• Mammalian Cell Selection: Puromycin