Monoclonal antibody to DR4 (Clone: ABM1B11 )

DESCRIPTION

Death receptor 4 (DR4) or TRAIL-R1, a member of the tumor necrosis factor receptor superfamily, is a cell surface receptor that triggers the apoptotic machinery upon binding to its ligand tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). DR4 is expressed in most of human tissues including spleen, peripheral blood leukocytes, small intestine and thymus. DR4 expression is enhanced by DNA damage whether induced by ionizing radiation or by chemotherapeutic agents. On binding DR4, TRAIL induces cell death via caspase-dependent apoptosis. DR4 mediates oligomeric Abeta induction of extrinsic apoptotic pathways in human microvascular cerebral endothelial cells with activation of both caspase-8 and caspase-9. It is considered a promising molecular target for cancer therapy.

DETAILS

Gene: TNFRSF10A
App Id: FACS,WB
Antigen: DR4
Gene Id: 8797
Isotype: Mouse IgG1 Kappa
Format Id: Purified
Clone Name: ABM1B11
Uniprot Id: O00220
Host Animal: Mouse
Clonality Id: Monoclonal
Purification: Protein G Chromatography
Reactivity Id: Human
Product Content: 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Alternative Name: TNFRSF10A||APO2||DR4||TRAILR1
Application Note: Western blot analysis: 2-4 µg/ml, FACS analysis- 0.5-1 µg/10^6 Cells
Storage Condition: Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
Immunogen Information: A partial length recombinant human DR4 protein (amino acids 2-203 was used as an immunogen for this antibody.