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150-16

Recombinant Human VAP-1

PeproTech

DETAILS

  • Gene Id: 8639
  • Uniprot: Q16853
  • Activity: Measured by its ability to produce hydrogen peroxide during the oxidation of benzylamine. The specific activity >16 pMoles/min/ug of VAP-1.
  • Category: RUO Cytokines
  • Subcategory: Growth Factors & Cytokines
  • Research Areas: Angiogenesis/Cardiovascular, Cancer, Immune System, Inflammation
  • Alternative Names: Vascular Adhesion Protein-1, AOC3, SSAO, HPAO, Copper Amine Oxidase, Membrane Primary Amine Oxidase
  • Species of Origin: Human
  • Expression System Source: CHO cells

DESCRIPTION

VAP-1 is a type II membrane cell adhesion protein belonging to the copper/topaquinone oxidase family. It is primarily expressed on the high endothelial venules of peripheral lymph nodes and on hepatic endothelia. VAP-1 can catalyze the oxidative deamination of low molecular weight amines, and plays an important role in the migration of lymphocytes to inflamed tissue. Inhibition of VAP-1 can protect against inflammation-related damage to certain injured tissues. Additionally, VAP-1 can function as a significant prognostic marker for certain cancers and cardiovascular diseases. Recombinant Human VAP-1 is a mixture of monomeric and disulfide-linked homodimeric forms of a 737 amino acid polypeptide, corresponding to amino acids 27 to 763 of the VAP-1 precursor. The calculated molecular weight of Recombinant Human VAP-1 is 81.8 kDa.