Dibutyryl-cAMP, sodium salt

DESCRIPTION

Dibutyryl-cAMP is a cell-permeable activator of cAMP-dependent protein kinases and phosphodiesterase inhibitor. It mimics endogenous cyclic adenosine monophosphate (cAMP). Dibutyryl-cAMP is reported to induce apoptosis in vascular smooth muscle cells and induce neurite growth.

DETAILS

Purity: ≥95%
Synonyms: Bucladesine sodium salt, Actosin, MLS001148197
Cas Number: 16980-89-5
References: Kahn, A. M., Dolson, G. M., Hise, M. K., Bennett, S. C., & Weinman, E. J. (1985). Parathyroid hormone and dibutyryl cAMP inhibit Na+/H+ exchange in renal brush border vesicles. American Journal of Physiology-Renal Physiology, 248(2), F212-F218. Leonard, J. L. (1988). Dibutyryl cAMP induction of type II 5′ deiodinase activity in rat brain astrocytes in culture. Biochemical and biophysical research communications, 151(3), 1164-1172. Rundfeldt, C., Steckel, H., Sörensen, T., & Wlaz, P. (2012). The stable cyclic adenosine monophosphate analogue, dibutyryl cyclo-adenosine monophosphate (bucladesine), is active in a model of acute skin inflammation. Archives of dermatological research, 304(4), 313-317.
Application: FA
Formulation: Crystalline solid
Chemical Name: sodium;[(4aR,6R,7R,7aR)-6-[6-(butanoylamino)purin-9-yl]-2-oxido-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-yl] butanoate
Molecular Weight: 491.4
Molecular Formula: C18H23N5O8P Na
Storage Conditions: Product should be kept at -20°C.
Pubchem Openeye Can Smiles: CCCC(=O)NC1=C2C(=NC=N1)N(C=N2)C3C(C4C(O3)COP(=O)(O4)[O-])OC(=O)CCC.[Na+]