mouse monoclonal IgG1; CNK1 Antibody (G-7) is an IgG1 κ mouse monoclonal CNK1 antibody (also designated CNK1 antibody) that detects the CNK1 protein of mouse, rat and human origin by WB, IP, IF and ELISA. CNK1 Antibody (G-7) is available as both the non-conjugated anti-CNK1 antibody form, as well as multiple conjugated forms of anti-CNK1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. CNK1 (connector enhancer of kinase suppressor of Ras 1), also known as KSR or CNKSR1, is a 720 amino acid cytoplasmic and membrane protein involved in the RAS-dependent signaling pathway. RAS is essential for integrating and transmitting proliferation, differentiation and survival signals elicited by membrane receptors to downstream effector pathways. RAF is part of the RAS dependent signaling pathway and is involved in the transduction of mitogenic signals from the cell membrane to the nucleus. CNK1 contains several protein-protein interaction domains and plays a key role as a tyrosine phosphorylation target in multiple receptor tyrosine kinase pathways. The C-terminal portion of CNK1 directly binds to RAF, blocking RAS- and RAF-dependent signaling when overexpressed. The N-terminal portion contains two domains that are critical for cooperation with RAS, and two CNK1 isoforms are produced due to alternative splicing events.

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.