1151436-50mg 1151436-10mg
CNQX
Biogems
DESCRIPTION
CNQX is a potent AMPA/kainate receptor antagonist. It also acts an antagonist to the NMDA receptor complex at the glycine site. It is reported to block the excitatory action of kainate and quisqualate on spinal neurons with little or no effect on that of NMDA.
DETAILS
- Purity: ≥98%
- Synonyms: 6-Cyano-2,3-dihydroxy-7-nitroquinoxaline, FG-9065
- Cas Number: 115066-14-3
- References: Blake, J. F., Brown, M. W., & Collingridge, G. L. (1988). CNQX blocks acidic amino acid induced depolarizations and synaptic components mediated by non-NMDA receptors in rat hippocampal slices. Neuroscience letters, 89(2), 182-186. Honoré, T., Drejer, J., Nielsen, E. Ø., & Nielsen, M. (1989). Non-NMDA glutamate receptor antagonist 3 H-CNQX binds with equal affinity to two agonist states of quisqualate receptors. Biochemical pharmacology, 38(19), 3207-3212. Long, S. K., Smith, D. A. S., Siarey, R. J., & Evans, R. H. (1990). Effect of 6‐cyano‐2, 3‐dihydroxy‐7‐nitro‐quinoxaline (CNQX) on dorsal root‐, NMDA‐, kainate‐and quisqualate‐mediated depolarization of rat motoneurones in vitro.British journal of pharmacology, 100(4), 850-854.
- Application: FA
- Formulation: Crystalline solid
- Chemical Name: 7-nitro-2,3-dioxo-1,4-dihydroquinoxaline-6-carbonitrile
- Molecular Weight: 232.2
- Molecular Formula: C9H4N4O4
- Storage Conditions: Product should be kept at -20°C.
- Pubchem Openeye Can Smiles: C1=C(C(=CC2=C1NC(=O)C(=O)N2)[N+](=O)[O-])C#N