DESCRIPTION

• Target: PP5
• Gene Id: 5536
• Isotype: IgG1
• Conjugate: RPE
• Immunogen: Full length human PP5 protein
• References: 1. Butzow R., et al. (1988) J Lab Clin Med. 111(2): 249-256.
• Swiss-prot: P53041
• Specificity: Detects ~58kDa.
• Applications: WB | ICC/IF
• Clone Number: 12F7
• Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
• Host Species: Mouse
• Product Type: Monoclonal
• Purification: Protein G Purified
• Concentration: 1 mg/ml
• Research Areas: Cell Signaling | Epigenetics and Nuclear Signaling
• Storage Buffer: PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
• Accession Number: NP_006238.1
• Alternative Names: PPP5 Antibody, PPT Antibody, Protein phosphatase T Antibody, Serine/threonine protein phosphatase 5 Antibody
• Antibody Dilution: WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
• Cite This Product: StressMarq Biosciences Cat# SMC-244D-RPE, RRID: AB_2699626
• Immunogen Species: Human
• Storage Temperature: Conjugated antibodies should be stored at 4ºC
• Shipping Temperature: Blue Ice or 4ºC
• Cellular Localization: Nucleus | Cytoplasm
• Scientific Background: Proteins in this family participate in pathways regulated by reversible phosphorylation at serine and threonine residues, potentially playing a role in the regulation of cell growth and differentiation. PP5 or PPT is predominantly a nuclear protein and interacts with CDC16 and CDC27. It is found in association with several proteins that influence intracellular signlaing-cascades intitiated by hormones (glucocorticoids) or cellular stress (hypoxia, oxidative stress and DNA Damage). It phosphorylates serine residues of skeletal muscle phosphorylase and histone H1. It may also be involved in mitosis and RNA biogenesis regulation (1,2).
• Certificate of Analysis: 1 µg/ml of SMC-244 was sufficient for detection of PP5 in 15 µg of human A431 lysates by ECL analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
• Species Reactivity Full Name: Human