Mouse TL1A Protein, His Tag (HPLC-verified)

DESCRIPTION

TNF-like cytokine 1A (TL1A) and its receptors, death receptor 3 (DR3) and decoy receptor 3 (DcR3) are members of the TNF and TNF receptor superfamilies of proteins, respectively. Binding of APC-derived TL1A to lymphocytic DR3 provides co-stimulatory signals for activated lymphocytes. DR3 signaling affects not only the proliferative activity of and cytokine production by effector lymphocytes, but also critically influences the development and suppressive function of regulatory T-cells. Whereas, DcR3 restricts the function of the TL1A/DR3 complex: attenuating T-cell activation and downregulating the secretion of pro-inflammatory cytokines. Together with DR3 and DcR3, TL1A constitutes a cytokine system that actively interferes with the regulation of immune responses.

DETAILS

Tag: N-10×His
Host: HEK293
Size: 1mg
Buffer: PBS, pH7.4, 0.2 M Arginine
Format: Powder
Purity: 90%
Source: Mouse TL1A , His Tag (TLA-M5243) is expressed from human 293 cells (HEK293). It contains AA Ala 61 - Leu 252 (Accession # Q5UBV8-1).
Storage: -20℃
Category: Other Recombinant Proteins
Molecule: TL1A
Accession: Q5UBV8-1
Conjugate: Unconjugated
Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Exp Region: Ala 61 - Leu 252
Swiss-prot: Q5UBV8-1
Package Size: 500ug*2
Characteristics: This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 23.4 kDa. The protein migrates as 27-29 kDa and 30-33 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level: 1.0 EU per μg
Molecular Weight: 23.4 kDa
Shipping Condition: RT
Species Reactivity: Mouse
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