Anti-ARPC2 Antibody [JE58-79]

DESCRIPTION

Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the mother actin filament. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs). Two alternatively spliced variants have been characterized to date. Additional alternatively spliced variants have been described but their full length nature has not been determined.

DETAILS

Host: Rabbit
Type: Primary
Uniprot: SwissProt: O15144 Human;SwissProt: Q9CVB6 Mouse;SwissProt: P85970 Rat
Clone Id: JE58-79
Clonality: Recombinant Rabbit monoclonal Antibody
Conjugate: Non-conjugated
Alias Names: Actin related protein 2/3 complex subunit 2 34kDa antibody Actin related protein 2/3 complex subunit 2 antibody Actin-related protein 2/3 complex subunit 2 antibody ARC 34 antibody ARC34 antibody Arp2/3 complex 34 kDa subunit antibody ARP2/3 protein compex subunit 34 antibody ARPC 2 antibody Arpc2 antibody ARPC2_HUMAN antibody p34 Arc antibody p34-ARC antibody p34Arc antibody PNAS 139 antibody PNAS139 antibody PRO 2446 antibody PRO2446 antibody
Application: WB,IHC-P
Epitope Region: Recombinant protein within human ARPC2 aa 201-300/300.
Protein Target: ARPC2
Target Species: Human,Mouse,Rat
Species Reactivity: Human,Mouse,Rat