DESCRIPTION

• Aa: 2-538 (end)
• Mw: 60 kDa
• Tags: N-terminal His-tag
• Format: Aqueous buffer solution
• Genbank: NM_005057
• Species: Human
• Uniprot: Q15291
• Shiptemp: -80°C (dry ice)
• Synonyms: Rbbp5, retinoblastoma binding protein 5, Set1c WD40 Repeat Protein, SWD1, RBQ3
• Warnings: Avoid freeze/thaw cycles.
• Category: Other Protein/Other Protein
• Background: RbBP5 binds directly to retinoblastoma protein, which regulates cell proliferation. It interacts preferentially with the underphosphorylated retinoblastoma protein via the E1A-binding pocket B. In embryonic stem (ES) cells, RbBP5 plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3Lys4 methylation at key developmental loci, including that mediated by retinoic acid. As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at Lys4 of histone H3.
• References: 1. Cao, F., et al., PLoS One. 2012 Nov 23; 5(11): e14102.2. Odho, Z., et al., J Biol Chem. 2010 Oct 22; 285(43): 32967-76.
• Description: Human retinoblastoma binding protein 5 (RbBP5), GenBank Accession No. NM_005057, a.a. 2 - 538 (end) with N-terminal His-tag, MW= 60 kDa, expressed in an E. coli expression system.
• Formulation: 20 mM Tris-HCl, pH 7.4, 300 mM NaCl, 10% glycerol, 1 mM TCEP, and 1 µM ZnCl2
• Unspsc Code: 12352202
• Unspsc Name: Proteins
• Applications: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. 
• Product Type: Protein
• Biosafety Level: Not applicable (BSL-1)
• Storage Stability: At least 6 months at -80°C.
• Scientific Category: Miscellaneous